Fig. 3
From: A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis
Immunohistochemical studies performed on the cerebellar lesion. A, PAX8 is largely negative within the undifferentiated tumor cells but shows nuclear positivity in the regions with epithelioid morphology. B, GFAP shows diffuse positivity within the tumor. C, Cam5.2 highlights the epithelioid structures. D, INI1 expression is lost within the tumor cells with internal positive control showing retained expression in background non-neoplastic tissue. E, H3K27M stain is negative. F, H3K27me3 stain shows loss of nuclear expression within the tumor cells with internal positive control demonstrating intact expression within the non-neoplastic cells