Fig. 1
From: A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis
Histomorphologic evaluation of the CT-guided liver biopsy of the metastatic renal medullary carcinoma. A, H&E stained section showing atypical epithelioid cells with abundant eosinophilic cytoplasm arranged in glands and embedded in a desmoplastic stroma. B, PAX8 shows strong, diffuse nuclear positivity within the neoplastic cells. C, INI1 shows high background staining, but demonstrates loss of nuclear expression, similar to the external control, within the tumor cells. D, A recent kidney biopsy performed confirms the absence of nuclear INI1 expression in the primary tumor cells with appropriate internal positive control E, H3K27me3 stain highlighting intact nuclear expression in both neoplastic cells and background stromal cells