Fig. 2

Increased transcript levels of genes associated with EMT, Matrisome, and the KRAS signaling pathway. Median normalized transcript counts from melanoma cells isolated from brain, lung and meninges compared with three independently grown populations of B16-F0. Genes were selected that were found in each pairwise GSEA analysis between B16-F0 and B16-derived brain, lung and meninges cells with a rank metric score > 1. Overlapping genes between the three molecular signatures are shown in blue. Medians are re-scaled from 0 to 1