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Table 1 Demographic and clinical characteristics of ALS patients with P36R mutation in ANXA11

From: Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment

Clinical features

ALS patients with P36R mutation (n = 10)

Male: Female

1:1

Age at onset (years), average ± SD

72.30 ± 5.53

Survival time (months), average ± SD

29.60 ± 7.86

Phenotype

ALS

1

ALSci

3

ALS-FTD

6

Site of onset, bulbar% (bulbar: limb)

70% (7:3)

Family history, Yes% (Yes: No)

90% (9:1)

  1. ALS amyotrophic lateral sclerosis; ALSci amyotrophic lateral sclerosis with cognitive impairment; FTD frontal–temporal dementia
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Acta Neuropathologica Communications

ISSN: 2051-5960

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