Fig. 3
From: Decoding TDP-43: the molecular chameleon of neurodegenerative diseases
The multifaceted roles of TDP-43 in DNA interactions and chromatin dynamics This circular diagram illustrates the diverse functions of TDP-43, centered around three main categories: DNA Interactions, Chromatin Silencing, and Transcriptional Machinery. It shows TDP-43’s involvement in DNA binding (promoter, ssDNA, dsDNA), repressive and activating gene regulation, lncRNA interactions, and retrotransposon silencing. The figure also highlights TDP-43’s role in histone modifications (including H3K9me3, H3K4me3, H3S10Ph-K14Ac), interactions with histone deacetylases, DNA methylation, and its impact on transcription factors and mediator complex subunits. This comprehensive representation underscores TDP-43’s critical role in regulating gene expression and maintaining genomic stability