Sarcomatous transformation of IDH-mutant astrocytoma matching to methylation class oligosarcoma following embolization, a case report

Table 2 Methylation classes as determined by the DKFZ/Heidelberg classifier v12.8

Level	Predicted classification	Classifier score
Initial resection
Super Family	Adult-type diffuse gliomas	0.99
Family	Diffuse glioma, IDH-mutant	0.99
Subclass	Astrocytoma, IDH-mutant,	0.89
	Lower grade
	Oligodendroglial type
Subclass	Oligodendroglioma, IDH-mutant,	0.11
	1p/19q co-deleted
Recurrent resection
Gliomatous morphology
Super family	Adult-type diffuse gliomas	0.99
Family	Diffuse glioma, IDH-mutant	0.99
Class	Diffuse glioma, IDH-mutant,	0.99
	Astroglial type
Subclass	Astrocytoma, IDH-mutant,	0.99
	Lower grade
Recurrent resection
Sarcomatous morphology
Super family	Adult-type diffuse gliomas	0.95
Family	Diffuse glioma, IDH-mutant	0.91
Class	Diffuse glioma, IDH-mutant,	0.91
	Oligodendroglial type
Subclass	Oligosarcoma, IDH-mutant	0.90

The initial resection matched to astrocytoma, IDH-mutant, with an unusual result from the classifier returning a minor minor degree of oligodendroglioma (top). The recurrent tumor matched with high confidence to astrocytoma, MC IDH-mutant, low-grade, in the glial component (middle) and MC Oligosarcoma, IDH-mutant, in the sarcomatous component (bottom)

ISSN: 2051-5960