Fig. 3

Chromosomal Microarray of initial and recurrent tumor. Copy number plots from chromosome 1p (left) to Y (right) for the initial resection (A) and recurrence (B). The initial resection (A) shows loss of chromosome 9/CDKN2A/B (red arrow) and LOH at chromosome 17q, including the TP53 locus (blue arrow). No 1p/19q co-deletion was observed. Recurrent tumor (B) showed a complex karyotype with retained 17q LOH breakpoint but no co-deletion nor LOH at 1p/19q. Expanded chromosome 17 plots (C), which correspond with blue and pink boxes in A and B, showed loss of heterozygosity with the same breakpoint (green arrow) in both initial sample (blue) and recurrent sarcomatous tumor (pink)