Fig. 2

Histology of initial resection and tumor recurrence. Hematoxylin and eosin-stained sections of A the initial resection demonstrating an infiltrative astrocytic neoplasm with irregular nuclear morphology and mitotic activity and B–C the re-resection specimen showing sarcomatous morphology. Stains on the re-resection specimen demonstrates D ATRX loss in the tumor and with retained expression in surrounding parenchyma, E reticulin fiber staining within the tumor, and F GFAP loss in the tumor with retained surrounding expression