Fig. 8

The pTau pathology in the V1 of 6-month-old TAU58 mice brain after subretinal injection of brain lysates. a: Schematic representation of a coronal section showing the delineated layers of V1. The Kruskal-Wallis test, followed by Dunn’s tests, was conducted within the layers of the V1 in the left (b, d, f, h, j, l) and right (c, e, g, i, k, m) hemispheres. h: Significant differences were observed in the number of pTau-positive neurons in the Internal Pyramidal Layer of the V1 between the PBS and AD brain homogenate injected groups (p = 0.0318). No significant difference in the number of pTau-positive neurons was found between the seed injection groups for panels a, b, c, d, e, f, h, i, j, k, and l. The schematic figure in a was made with the help of the Allen Institute for Brain Science. (2011), pp. http://mouse.brain-map.org. Error bars: Min to Max.V1 = primary visual area, VISp1 = Molecular Layer, VISp2/3 = External Granular and External Pyramidal Layer, VISp4 = Granular Layer, VISp5 = Internal Pyramidal Layer, VISp6a = Multiform Layer (sublayer), VISp6b = Multiform Layer (sublayer), LGN = lateral geniculate nucleus