Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates

Fig. 3

Patient-derived homogenates induce seeding in the pTau biosensor cell lines. a-c: A Tau (P301S) biosensor cell line underwent incubation with sarkosyl-insoluble homogenates from the temporal cortex of 1 non-AD/PART case and 1 AD case; a non-treated cell line served as a control. AD brain homogenates exhibited increased pTau seeding, indicated by an increase in green spots (indicated by white arrows), compared to the non-AD/PART case. d: After 48 h, the number of positive pTau spots/cells was automatically quantified, and the one-way ANOVA with Tukey’s multiple comparisons test revealed a significant difference (p < 0,0001) between the analyzed cases. Error bars: Min to Max in d

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us