Fig. 7
From: The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function
Depletion of CUL4B in the nervous system results in impaired spatial learning and memory. (a) Escape latency (time spent prior to finding the platform) was measured during 5 consecutive days of training in the Morris water maze test (N = 10 mice). (b) Representative traces of the real path of the probe trail in the Morris water maze test. (c) The movement time spent in the target quadrant, in which the platform was originally placed, in the probe trial (N = 10 mice). (d) The number of times the mice crossed the circle where the platform was originally placed (N = 10 mice). (e) Swimming velocity of the mice in the Morris water maze test (N = 10 mice). (f) Swimming distance of the mice in the Morris water maze test (N = 10 mice). (g) Activity trajectories of the mice in the Y maze monitored by an infrared video recorder within 8 min. (h) The number of total entries of the mice into the arms of the Y maze (N = 8 mice for CON and 12 mice for CKO). (i) The percentage of alternation ratio of the mice that traveled in the Y maze (N = 8 mice for CON, and 12 mice for CKO). * P < 0.05; ** P < 0.01; **** P < 0.0001; ns, not significant