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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: 3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer’s disease via machine learning

Fig. 7

Differences in retinal microglia with respect to phagocytic cups between AD and controls. A Example image of an AD retina with microglia labelled with IBA-1 (green) and CD68 (red) a transmembrane glycoprotein embedded in lysosomal membrane, with phagocytic cups indicated with yellow arrows. B Column graph comparing the average number of cups/microglia between control and AD retina using manual analysis. C Column graph comparing the average number of CD68 + cups/microglia between control and AD retina using manual analysis. D Column graph comparing the fraction of CD68 + cups/total number of cups between control and AD retina using manual analysis. Points represent individual image averages and error bars represent standard error of the mean. P-values for Mann–Whitney U test are below their respective column graphs. (For B–D: Ctrl, n = 4 subjects; AD, n = 5 subjects) (Ctrl = Control; AD = Alzheimer’s disease)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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