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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals

Fig. 5

GO analysis indicates L3 and L5 PNs in DS show unique and lamina specific processes. A. Venn diagram indicates L3 uDEGs and L5 uDEGs represent a subset of the GO processes dysregulated in each layer, with L3 PNs having more dysregulated processes than L5 PNs. B. Donut chart shows comparison of L3 LS GO processes. The inner donut depicts the relative number of processes per bin and the outer donut is the average percentage of total DEGs from L3A compared to L3 uDEGs per process in each bin. C. Donut chart of L5 uDEG and all L5 DEG GO processes with the inner donut indicating relative amounts of dysregulated LS processes in each bin and the outer donut showing the mean percentage of uDEGs driving the processes within each bin

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Acta Neuropathologica Communications

ISSN: 2051-5960

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