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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals

Fig. 4

IPA pathway changes were seen with uDEGs from either DS L3 or L5 PNs. A. Select canonical pathways were identified as unique to L3 uDEGs by comparing IPA results from L3 uDEGs to IPA results from L3A DEGs, L5 uDEGs, and L5A DEGs. B. L5 uDEGs were analyzed by IPA and compared to all groups as in (A) with select L5 uDEG pathways shown. C. A subset of the L3 unique disease and functions are shown. D. Select L5 unique disease and functions are shown. Key: -Log(p-value) shown in white-blue, while z-score is shown with upregulated pathways in red and downregulated pathways in green. Cross hatch in z-score indicates the IPA program cannot estimate regulatory status of this dysfunctional pathway

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Acta Neuropathologica Communications

ISSN: 2051-5960

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