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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals

Fig. 3

Lamina specific pathway changes were seen in DS L3 and L5 PNs. A. L3 uDEGs were analyzed by IPA and compared to L3A, L5 uDEG, and L5A IPA results. Select canonical pathways only dysregulated in L3 PNs are depicted using L3 uDEG -Log(p-value) and z-scores. B. L5 uDEGs were analyzed by IPA and compared to all groups as (A) with select L5 layer specific pathways shown. C. A subset of the L3 layer specific disease and functions indicated many D/Fs are divergently dysregulated in L3 and L5 (*). D. Select L5 layer specific disease and functions shown (*) marking divergent expression in L3 uDEGs. Key: -Log(p-value) shown in white-blue, while z-score is shown with upregulated pathways in red and downregulated pathways in green with white indicating a z-score of 0. Cross hatch in z-score indicates the IPA program cannot estimate regulatory status of this dysfunctional pathway

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Acta Neuropathologica Communications

ISSN: 2051-5960

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