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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals

Fig. 1

RNA-seq of BA9 L3 and L5 DS PNs exhibit unique and divergent gene expression. (A) Schematic representation of the L3 and L5 gene expression paradigm to isolate unique and divergently expressed genes in L3 or L5 PNs in DS compared to CTRs for downstream analysis. (B) Correlation plot shows dark red dots represent each DEG solely dysregulated in L3 or L5 shown as LFC. Light red dots represent divergent genes are upregulated in L5 and downregulated in L3 (top left quadrant) or vise-versa (bottom right quadrant). C, D. Volcano plots show L3 (C) or L5 (D) unique and divergent DEGs at a stringency of p < 0.01 (up, dark red; down, dark blue) and p < 0.05(up, red; down, light blue). E, F. Bar charts show L3 uDEGs (E) and L5 uDEGs (F) binned by LFC, indicating slightly more upregulated genes (purple) than downregulated (green) in DS compared to CTR cortical pyramidal neurons

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Acta Neuropathologica Communications

ISSN: 2051-5960

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