Table 3 Comparison of diagnostic accuracy of metrics of different cut-offs for p16 IHC retention
Metric | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
5% cut-off | 89.6% ± 5.8% | 91.3% ± 3.7% | 82.6% ± 6.9% | 95.0% ± 2.9% |
1% cut-off | 71.2% ± 7.1% | 71.7% ± 5.7% | 62.4% ± 7.1% | 79.1% ± 5.4% |
Complete absence as cut-off | 77.2% ± 9.2% | 80.0% ± 4.9% | 54.5% ± 9.2% | 91.9% ± 3.6% |