Fig. 6

Enhancing margin thickness and regulatory T cells transcription factors in the blood. The thickness of the enhancing margin (which is assessed semiquantitatively as an ordinal variable in the VASARI methodology: 1 = thin, 2 = thick, 3 = solid) correlated significantly with a lower abundance of regulatory T cells factors in the peripheral blood (a), as measured via Spearman correlation that is the adequate test for correlating semiquantitative/ordinal variables with quantitative variables. As illustration, an example of a patient with a relatively thin enhancing margin (b) and a patient with a relatively thick enhancing margin (c) are given - like in Fig. 3. Regulatory T cell factors here means a compund metric that integrates all measured regulatory T cell factors (i.e. IL-10, FoxP3, TGFbeta) to capture the concerted polarizing effect they have