Fig. 3

Enhancing margin thickness and central memory CD8+ cells in the blood. The thickness of the enhancing margin (which is assessed semiquantitatively as an ordinal variable in the VASARI methodology: 1 = thin, 2 = thick, 3 = solid) correlated significantly with the abundance of central memory CD8+ cells in the peripheral blood (a), as measured via Spearman correlation that is the adequate test for correlating semiquantitative/ordinal variables with quantitative variables. As illustration, an example of a patient with a relatively thin enhancing margin (b) and a patient with a relatively thick enhancing margin (c) are given