Fig. 4

Diagnostic value of SCNA profiling of cell-free DNA from cerebrospinal fluid of patients with CNS cancers. A Concordance analyses between CSF and tumor tissue. Depicted is the fraction of SCNAs private to CSF (blue), private to tissue (gray) or shared between the two (red). B Circos plots with copy number profiles of CSF cfDNA compared to tissue DNA exemplifying the usefulness of SNCA profiling for minimal invasive detection of CNS cancer, molecularly informed diagnostic assessment, mapping of tumor heterogeneity and tracking tumor evolution as well as surveilling patients with a previous cancer diagnosis