Fig. 2

Somatic copy number aberrations in cell-free DNA from cerebrospinal fluid of patients with CNS cancers. A Overview clinical diagnosis and SCNA parameters. CSF cfDNA SCNA positivity vs. negativity and comparison of SCNA profiles in CSF and corresponding tissue (shared SCNAs) are depicted. B Frequency of detection of somatic copy number aberrations (SCNAs) across various CNS cancer types. SCNA positive samples are shown in green, negative samples in red. C SCNA parameters (CNI score, aberrant bin count, tumor cfDNA fraction) across the tumor patients. D Circos plots showing the copy number profile of cfDNA from cerebrospinal fluid of three exemplarily tumor patients with a high or medium CNI score in contrast to a patient without SCNAs