Multiparametric grading of glaucoma severity by histopathology can enable post-mortem substratification of disease state

Xiang, Chuanxi; Raghunathan, VijayKrishna; Qiu, Yubin; Mehta, Manisha; Demirs, John T.; Grosskreutz, Cynthia L.; Wilson, Christopher W.; Prasanna, Ganesh

doi:10.1186/s40478-024-01880-2

Table 1 Donor demographics

From: Multiparametric grading of glaucoma severity by histopathology can enable post-mortem substratification of disease state

Donor #	Disease state	Age	Eye	Sex	Race/ethnicity	Recent medical history	Used for IHC portion of study
1	Non-glaucoma	81	OS	male	Caucasian	Acute cardiac crisis	No
2	Non-glaucoma	73	OS	male	Caucasian	Leukemia	Yes
3	Non-glaucoma	84	OS	male	Caucasian	Acute cardiac crisis	Yes
4	Non-glaucoma	92	OS	male	Caucasian	Cardiac arrest	Yes
5	Non-glaucoma	72	OS	male	Caucasian	Colon cancer	No
6	Non-glaucoma	84	OS	female	Caucasian	Multiple myeloma	Yes
7	Non-glaucoma	77	OS	male	Caucasian	Sepsis	Yes
8	Non-glaucoma	94	OS	male	Caucasian	COPD	Yes
9	Non-glaucoma	84	OS	male	Caucasian	Severe PVD	Yes
10	Non-glaucoma	78	OS	male	Caucasian	CHF, CVA	Yes
11	Non-glaucoma	79	OS	female	Caucasian	Leukocytosis, bowel perforation	No
12	Non-glaucoma	90	OS	female	Caucasian	Hospice care, failure to thrive	No
13	Non-glaucoma	74	OS	male	Caucasian	Colon cancer, cirrhosis	No
14	Non-glaucoma	76	OS	male	Caucasian	COPD	No
15	Non-glaucoma	83	OS	female	Caucasian	Trauma, hospice	Yes
16	Non-glaucoma	84	OS	male	Caucasian	End stage lung cancer	No
17	Non-glaucoma	88	OS	female	Caucasian	Pneumonia	Yes
18	Non-glaucoma	83	OS	female	Caucasian	Lung cancer with mets, pneumonia	Yes
19	Non-glaucoma	83	OS	female	Caucasian	Lung cancer, atrial fibrillation	Yes
20	Non-glaucoma	68	OS	male	Hispanic	Cellulitis of leg, severe PVD, limb ischemia	Yes
21	Non-glaucoma	80	OS	male	Caucasian	Acute cardiac crisis	No
22	Non-glaucoma	92	OS	female	Caucasian	Pneumonia, respiratory failure	No
23	Non-glaucoma	97	OS	female	Caucasian	Fecal impaction, weakness, pleural effusion	No
24	Non-glaucoma	99	OS	female	Caucasian	Renal failure	No
25	Non-glaucoma	94	OD	female	Caucasian	Sepsis	Yes
26	Non-glaucoma	75	OS	male	Caucasian	Pancreatitis	Yes
27	Non-glaucoma	78	OS	male	Caucasian	Renal failure	No
28	Non-glaucoma	75	OS	male	Caucasian	Type 2 diabetes	No
29	Non-glaucoma	79	OS	female	Caucasian	Anemia, HTN, COPD	Yes
30	Non-glaucoma	97	OS	female	Caucasian	Acute cardiac event	No
31	Non-glaucoma	77	OS	female	Caucasian	Cardiac event	No
32	Glaucoma	73	OS	male	Caucasian	Prostate cancer	Yes
33	Glaucoma	86	OS	male	Caucasian	Metabolic encephalopathy	Yes
34	Glaucoma	87	OS	male	Caucasian	Skin cancer	Yes
35	Glaucoma	97	OS	male	Caucasian	Acute cardiac crisis	Yes
36	Glaucoma	76	OS	female	Caucasian	MRSA	Yes
37	Glaucoma	65	OS	female	Caucasian	COPD, pneumonia	Yes
38	Glaucoma	79	OS	female	Caucasian	Pneumonia	Yes
39	Glaucoma	92	OD	female	Caucasian	Acute myeloid leukemia	Yes
40	Glaucoma	78	OS	female	Caucasian	Pneumonia	Yes
41	Glaucoma	77	OS	male	Caucasian	COPD, pneumonia	Yes
42	Glaucoma	93	OS	male	Caucasian	Pancreatic cancer	Yes
43	Glaucoma	88	OS	male	Caucasian	Renal failure	Yes
44	Glaucoma	80	OS	female	Caucasian	Acute myeloid leukemia	Yes
45	Glaucoma	68	OS	female	Black	Ichthyophthirius multifiliis	Yes
46	Glaucoma	83	OS	male	Asian	Fecal impaction, Weakness, Pleural effusion	Yes
47	Glaucoma	90	OS	male	Caucasian	Acute cardiac event	Yes
48	Glaucoma	85	OS	female	Caucasian	Acute kidney injury	Yes
49	Glaucoma	77	OS	female	Caucasian	COPD, respiratory failure	Yes
50	Glaucoma	71	OS	male	Caucasian	COPD, pneumonia	Yes
51	Glaucoma	70	OD	male	Caucasian	COPD, dementia	Yes
52	Glaucoma	78	OD	female	Caucasian	Intracerebral bleed	Yes

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ISSN: 2051-5960

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