Fig. 7

DMCs independent of cellular composition associated with high tumor immune infiltration. A–C EWAS analysis comparing GBM glioma to AST glioma in the Capper et al. dataset using A Model 1 and B Model 5. C Summarized results of all models used to compare tumor types. D–F EWAS analysis comparing the highest immune infiltrating GBM glioma to the lowest immune infiltrating GBM glioma in the Capper et al. dataset using D Model 1 and E Model 5. F Summarized results of all models used to compare high and low infiltrating GBM gliomas. Model 1: Univariable analysis. Model 2: Controlled for tumor proportion. Model 3: Controlled for proportions of tumor, angiogenic, glial and immune cells. Model 4: Controlled for proportions of tumor, angiogenic, astrocyte, microglia, oligodendrocyte, myeloid, and lymphoid cells. Model 5: Controlled for proportions of tumor, angiogenic, astrocyte, microglia, oligodendrocyte, T cell, B cell, NK, neutrophil, and monocyte cells. Ref reference group, DMCs differentially methylated CpGs, Hyper number of hypermethylated DMCs, Hypo number of hypomethylated DMCs