Fig. 2

CpGs selected for the L0 layer in the GIMiCC hierarchical deconvolution and accuracy of purity predictions. A Rows of the heatmap represent CpGs, the columns represent the average methylation value in the sample group in the test set of the Capper et al. dataset [39], and the color are representative of the methylation level of the sample at the specific CpG. The marks on the left of the figure denote which L0 library the CpG belonged to. Rows were organized via hierarchical clustering. B–D Correlation of GIMiCC estimated purity and the purity estimated in the Capper et al. manuscript [39, 66]. Circles denote samples from the test set, while crosses denote samples from the training set