Table 2 Comparison of diagnostic accuracy for PD with serum αSyn-SAA, saliva αSyn-SAA, or serum αSyn-SAA and saliva αSyn-SAA together
From: A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson’s disease
All serum | All saliva | Paired Serum-Saliva (ss-subset) | |||
|---|---|---|---|---|---|
Number of subjects | 82 PD, 42 HC | 83 PD, 48 HC | 48 PD, 26 HC | ||
Serum alone | Saliva alone | Both serum & saliva | |||
ThT fluorescence cutoff | 52,105 | 62,163 | 52,105 | 62,163 | serum: 52,960; saliva: 66,800 |
Sensitivity | 80.49% | 74.70% | 85.42% | 75.00% | 95.83% |
Specificity | 90.48% | 97.92% | 92.31% | 92.31% | 96.15% |
Accuracy by AUC (SE)a 95% CIb p value | 0.9006 (0.02724) 0.8472–0.9539 p < 0.0001 | 0.8966 (0.02614) 0.8454–0.9478 p < 0.0001 | 0.9623 (0.01866) 0.9258–0.9989 p < 0.0001 | 0.9046 (0.03337) 0.8392–0.9701 p < 0.0001 | 0.98 (0.011) 0.96-1.0 p < 0.001 |