Fig. 2
From: A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson’s disease
Comparison of αSynD Seeding Activity in Serum or Saliva Samples from Patients with PD and Healthy Controls (HC) by αSyn-SAA. Scatter graphs of RT-QulC endpoint ThT fluorescence intensities (αSynD seeding activities) in serum samples (A) or saliva samples (C) from patients with PD and HC subjects. Graphed are the average of the endpoint ThT fluorescence in quadruplicate wells of 124 serum samples (42 HC, 82 PD) or 131 saliva samples (48 HC, 83 PD) in RT-QuIC assays as a percentage of the maximum fluorescence (%ThT fluorescence). ThT fluorescence cutoff: serum, 52,105; saliva, 62,613. **** p < 0.0001. ROC curves for αSynD seeding activities in 124 serum samples (B) or 131 saliva samples (D) from patients with PD and HC subjects. SE, standard error. 95% CI, 95% confidence interval.