Fig. 1

snRNAseq of four regions of human post mortem brain from HD donors and controls. A. Sample summary. B. UMAP plot of all nuclei across brain regions, disease and control, showing all major cell types in the brain. C. The proportion of total nuclei identified as medium spiny neurons in the CN (PPP1R1B+) is reduced in HD compared to control (plot shows median and range). D Expression of canonical markers for cell lineages, across glial populations. E UMAP plots of astrocytes, microglia and oligodendroglia (L-R), showing annotated subclusters. BAM = border-associated macrophages