Fig. 1

Characterization of blood vessel permeability and brain basal water content. (a) Aligned dot plot showing quantitation of Evans Blue extravasation in WT (red), AQP4ex-KO (blue) and OAP-null (green) mice brain after intracaudal injection of dye. No differences among genotypes are observed (n = 5 for each analyzed group). The CTRL value is from a non-perfused animal. (b) Basal brain water content expressed in percentage. Aligned dot plot shows significantly reduced brain water content in AQP4ex-KO brain compared to WT and OAP-null. One-way ANOVA, Tukey’s multiple comparisons test, *p < 0.05, ***p < 0.0001; data are expressed as means ± SEM