Fig. 5

RNA-seq analysis of DEV 0 and DEV 4 treated and untreated retinal explants. a Principal component analysis (PCA) plot of DEV 0 and DEV 4 control solvent and Y-33075 RNA-seq analysis illustrating the distribution of gene expression of the samples for the three conditions. b Volcano plot identifying the differentially expressed genes (DEGs) in the Y-33075 treated group versus the control solvent group. Red dots represent the 131 genes that were significantly differentially expressed (padj < 0.05) with a fold-change ≤ − 2 or ≥+ 2 (− 2 ≤ log2FC ≥  + 2), of which 118 were downregulated and 13 upregulated in the Y-33075 treated condition