Fig. 8

Metabolomic profiles of optic nerves following high dose NAM given prophylactically (before the onset of HT) or as an intervention (after the onset of HT). These plots demonstrate that the metabolic profiles for high pressure eyes treated with high dose NAM differ significantly from high pressure eyes not treated with high dose NAM. A and B Principal component analysis of metabolomic profiles from normotensive eyes (N.HT, high pressure in the other eye), not receiving NAM treatment, compared with normotensive eyes (N.HT, high pressure in the other eye) receiving prophylactic or interventional, high dose NAM) The corresponding volcano plots are shown (C and D). E and F Principal component analysis of metabolomic profiles from eyes with high pressure (G.HT, normal pressure in the other eye), not receiving NAM treatment, compared with hypertensive eyes (G.HT, normal pressure in the other eye) receiving prophylactic or interventional, high dose NAM) The corresponding volcan plots are shown in G and H