Table 1 Relevant parameters of published CO transplantation studies
From: Organoids and chimeras: the hopeful fusion transforming traumatic brain injury research
Author | Year | Animal | Animal age | Sex | Lesion type | Time of transplant | Brain area of transplant | Follow-up |
|---|---|---|---|---|---|---|---|---|
Pham et al. | 2018 | NSG mice | 2 months | Male | Direct removal of brain tissue ∼ 2 × 2 × 2 mm | Immediately after injury | Cortex | 2 weeks |
Mansour et al. | 2018 | NOD-SCID mice | 6–10 weeks | Female (validated in male) | Aspirative cavity | Immediately after injury | Retrosplenial cortex | 8 months |
Daviaud et al. | 2018 | CD1 mice | P8-P10 | Male and female | Removal of brain tissue (∼ 1 mm3) with stab knife | Immediately after injury | Frontoparietal cortex | 4 weeks |
Wang et al. | 2019 | Sprague-Dawley rats | ---- | Male | MCAO + biopsy punch | 6 h/24 h/7 days after injury | Motor cortex | 28 days |
Kitahara et al. | 2020 | SCID mice; Macaca fascicularis | Mice: 7 days/6 weeks Monkeys: 3 years | Mice: male and female (7d), male (6w) Monkeys: male | Aspirative cavity | Immediately/7 days after injury | Mice: frontoparietal/frontal cortex Monkeys: precentral cortex | 12 weeks |
Wang et al. | 2020 | Sprague-Dawley rats | ---- | Male | Biopsy punch | Immediately after injury | Motor cortex | 56 days |
Shi et al. | 2020 | NOD-SCID mice | 8 weeks | ---- | Aspirative cavity | Immediately after injury | S1 cortex | 60 days |
Dong et al. | 2020 | SCID mice | 6–8 weeks | ---- | No lesion | Medial prefrontal cortex | 5 to 6 months | |
Bao et al. | 2021 | SCID mice | 8 weeks | ---- | CCI | 7 days after injury | Parietal cortex | 70 days |
Revah et al. | 2022 | RNU nude rats | P3-P7 | Male and female | No lesion | S1 cortex | 8 monthsa | |
Wilson et al. | 2022 | NOD-SCID mice | 8–12 weeks | Female | Aspirative cavity (∼ 1 mm diameter) | Immediately after injury | Retrosplenial cortex | 11 weeks |
Huang et al. | 2022 | SCID mice | 4–5 weeks | Female | No lesion | Corpus striatum | 60 days | |
Kim et al. | 2022 | C57BL/6 J mice | ---- | Male | CCI + biopsy punch | 7 days after injury | Cortex above hippocampus | 14 days |
Jgamadze et al. | 2023 | Long Evans rats | 8–12 weeks | Male | Aspirative cavity | Immediatly after injury | Visual cortex | 3 months |
Zheng et al. | 2023 | SCID mice | 8–12 weeks | ---- | 6-OHDA injection | 4 weeks after injury | Corpus striatum | 16 weeks |
Cao et al. | 2023 | NOD-SCID mice | 7–8 weeks | Male | Photothrombotic stroke | 7 days after injury | Forelimb motor/parietal cortex | 180 days |
Schafer et al. | 2023 | NOD-SCID mice | 6–10 weeks | Female (majority) | Aspirative cavity | Immediately after injury | Retrosplenial cortex | 24 weeks |
Cao et al. | 2023 | NOD-SCID mice | 7–8 weeks | Male | Photothrombotic stroke | 7 days after injury | Forelimb motor cortex | 180 days |
Chen et al. | 2024 | RNU nude rats | P3-P7 | Male and female | No lesion | S1 cortex | 9 months |