Table 2 Differentially expressed genes in the MAPT 17q.21.31 locus
From: MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy
Gene | Cerebellum | Temporal cortex | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
logFC | Average Expression | t-statistic | p value | FDR adjusted p value | Beta | LogFC | Average Expression | t-statistic | p value | FDR adjusted p value | Beta | |
MAPT | 0.279 | 8.898 | 6.698 | 3.53 × 10−10 | 6.91 × 10−8 | 12.783 | 0.159 | 8.789 | 2.537 | 0.012 | 0.064 |  − 3.356 |
KANSL1 | 0.268 | 6.754 | 5.615 | 8.67 × 10−8 | 2.56 × 10−6 | 7.432 | 0.182 | 5.533 | 3.834 | 1.82 × 10−4 | 4.09 × 10−3 | 0.297 |
NSF |  − 0.182 | 7.471 |  − 2.409 | 0.017 | 0.039 |  − 4.010 |  − 0.115 | 7.830 |  − 0.836 | 0.404 | 0.614 |  − 6.166 |
PLEKHM1 | 0.406 | 5.895 | 6.682 | 3.86 × 10−10 | 7.33 × 10−8 | 12.679 | 0.240 | 4.916 | 4.531 | 1.15 × 10−5 | 6.93 × 10−4 | 2.892 |
ARL17A | 0.023 | 5.007 | 0.264 | 0.792 | 0.848 |  − 6.775 |  − 0.014 | 3.887 |  − 0.151 | 0.880 | 0.940 |  − 6.545 |
LRRC37A |  − 0.576 | 3.113 |  − 3.951 | 1.17 × 10−4 | 6.28 × 10−4 | 0.797 |  − 0.606 | 2.312 |  − 3.474 | 6.63 × 10−4 | 9.24 × 10−4 |  − 0.646 |
ARHGAP27 |  − 0.195 | 3.869 |  − 2.379 | 0.019 | 0.041 |  − 3.911 |  − 0.242 | 3.537 |  − 2.688 | 7.96 × 10−3 | 0.048 |  − 3.024 |
CRHR1 |  − 0.141 | 4.523 |  − 1.108 | 0.270 | 0.370 |  − 6.151 |  − 0.021 | 2.887 |  − 0.143 | 0.887 | 0.944 |  − 6.381 |
ARL17B | 0.280 | 2.843 | 3.042 | 2.76 × 10−3 | 8.50 × 10−3 |  − 2.066 | 0.099 | 1.963 | 0.988 | 0.325 | 0.537 |  − 5.764 |