Fig. 2
From: MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy
Genes within the 17q21.31 locus are differentially expressed between progressive supranuclear palsy cases and controls. 10,011 genes were differentially expressed in the cerebellum (a) and 3579 genes were differentially expressed in the temporal cortex (b; p < 0.05, FDR adjusted). (c, d) MAPT, KANSL1, NSF, PLEKHM1, LRRC37A, and ARHGAP27 were differentially expressed in the cerebellum. KANSL1, PLEKHM1, LRRC37A, and ARHGAP27 were differentially expressed in the temporal cortex. ARL17A and CRHR1 were not differentially expressed in either brain region. e Map of the MAPT locus with location of genes examined. f IPA pathway analysis of top 5 canonical pathways from both the cerebellum and temporal cortex in order of p value, with z-score displayed