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Table 5 Multivariate binomial logistic regression analyses of predictors for dementia in pAGD and control cases

From: Pure argyrophilic grain disease revisited: independent effects on limbic, neocortical, and striato-pallido-nigral degeneration and the development of dementia in a series with a low to moderate Braak stage

 

OR

95% CI

p

Quantity of AGs in the amygdala

Model 1 (n = 50)

   

 Age at death

1.09

0.98–1.22

0.1122

 Braak NFT stages III-IV

2.08

0.34–12.79

0.4280

 One to 49 AGs in the amygdala (per × 400 visual field)

1.57

0.30–8.31

0.5928

 Presence of LATE-NC

2.51

0.27–23.78

0.4221

Model 2 (n = 50)

 Age at death

1.09

0.98–1.22

0.1159

 Braak NFT stages III-IV

1.74

0.26–11.74

0.5690

 50–99 AGs in the amygdala (per × 400 visual field)

2.43

0.17–34.96

0.5139

 Presence of LATE-NC

2.03

0.18–23.19

0.5689

Model 3 (n = 50)

 Age at death

1.07

0.95–1.20

0.2394

 Braak NFT stages III-IV

3.55

0.46–27.14

0.2224

 100 or more AGs in the amygdala (per × 400 visual field)

10.02

1.12–89.43

0.0391*

 Presence of LATE-NC

3.67

0.32–42.61

0.2985

Quantity of AGs in the hippocampal CA1

Model 4 (n = 51)

 Age at death

1.07

0.97–1.17

0.1669

 Braak NFT stages III-IV

3.08

0.55–17.23

0.1998

 One to 49 AGs in the CA1 (per × 400 visual field)

3.63

0.56–23.50

0.1754

 Presence of LATE-NC

5.13

0.57–45.82

0.1432

Model 5 (n = 51)

 Age at death

1.07

0.97–1.18

0.1913

 Braak NFT stages III-IV

2.83

0.49–16.29

0.2441

 20–99 AGs in the CA1 (per × 400 visual field)

0.76

0.08–7.03

0.8054

 Presence of LATE-NC

4.55

0.41–50.60

0.2176

Model 6 (n = 51)

 Age at death

1.07

0.97–1.17

0.1704

 Braak NFT stages III-IV

2.19

0.36–13.34

0.3954

 100 or more AGs in the CA1 (per × 400 visual field)

12.22

1.70–87.81

0.0128*

 Presence of LATE-NC

5.43

0.35–83.90

0.2258

Presence of AGs in the neocortex

Model 7 (n = 49)

 Age at death

1.06

0.95–1.18

0.2686

 Braak NFT stages III-IV

2.03

0.27–15.20

0.4890

 Presence of AGs in the lateral occipitotemporal gyrus

5.74

0.97–34.07

0.0544

 Presence of LATE-NC

2.05

0.18–24.03

0.5673

Model 8 (n = 49)

 Age at death

1.06

0.96–1.18

0.2484

 Braak NFT stages III-IV

1.61

0.19–13.75

0.6622

 Presence of AGs in the inferior temporal gyrus

8.18

1.03–65.13

0.0471*

 Presence of LATE-NC

3.33

0.28–38.96

0.3377

Combination of AGs in the amygdala, CA1, or neocortex

Model 9 (n = 49)

 Age at death

1.04

0.92–1.17

0.5015

 Braak NFT stages III-IV

1.82

0.17–19.62

0.6225

 Either 100 or more AGs per × 400 visual field in the amygdala or CA1 or the presence of AGs in the inferior temporal gyrus

13.92

2.12–91.49

0.0061**

 Presence of LATE-NC

5.72

0.39–83.79

0.2025

  1. 51 cases (23 pAGD cases and 28 control cases) that lacked two or more lacunae or larger infarctions in the cortex and/or subcortical regions were examined using multivariate analyses.
  2. pAGD pure argyrophilic grain disease, OR odds ratio, CI confidence interval, NFT neurofibrillary tangle, AG argyrophilic grains, LATE-NC limbic-predominant age-related TDP-43 encephalopathy neuropathologic change.
  3. *: p < 0.05, **: p < 0.01
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Acta Neuropathologica Communications

ISSN: 2051-5960

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