Table 2 Count of plaques and cerebral amyloid angiopathy (CAA) by Alzheimer’s Disease Neuropathologic Change (ADNC)
From: Machine learning quantification of Amyloid-β deposits in the temporal lobe of 131 brain bank cases
No/Not ADNC (n = 16) | Low ADNC (n = 30) | Intermediate ADNC (n = 23) | High ADNC (n = 62) | P value | |
|---|---|---|---|---|---|
Gray Matter | |||||
Cored Plaques, raw count, median (CI) | 0.5 (0, 4) | 6 (1, 38) | 283 (118, 484) | 265 (182, 333) | < 0.001 |
Diffuse Plaques, raw count, median (CI) | 0 (0,0) | 74.5 (25, 279) | 1358 (610, 2134) | 1998 (1764, 2433) | < 0.001 |
CAA, raw count, median (CI) | 0 (0, 11) | 1 (0, 10) | 5 (0, 11) | 3 (2, 5) | 0.055 |
Cored Plaques/µm², median (CI) | 0.00000000 (0.00000000, 0.00000002) | 0.000000025 (0.000000010, 0.000000210) | 0.00000121 (0.00000044, 0.00000190) | 0.00000101 (0.00000068, 0.00000120) | < 0.001 |
Diffuse Plaques/µm², median (CI) | 0 (0, 0) | 0.000000375 (0.000000090, 0.000001620) | 0.00000503 (0.00000309, 0.00000624) | 0.000007625 (0.000006140, 0.000008860) | < 0.001 |
CAA/µm², median (CI) | 0.00000000 (0.00000000, 0.00000003) | 0.00000000 (0.00000000, 0.00000002) | 0.00000001 (0.00000000, 0.00000004) | 0.00000001 (0.00000001, 0.00000002) | 0.182 |
White Matter | |||||
Cored Plaques, raw count, median (CI) | 0 (0, 2) | 0 (0, 0) | 11 (6, 27) | 17 (12, 22) | < 0.001 |
Diffuse Plaques, raw count, median (CI) | 0 (0, 0) | 0 (0, 1) | 5 (3, 31) | 18.5 (13, 25) | < 0.001 |
CAA, raw count, median (CI) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.89 |
Cored Plaques/µm², median (CI) | 0.00000000 (0.00000000, 0.00000004) | 0 (0, 0) | 0.00000023 (0.00000012, 0.00000042) | 0.00000025 (0.00000020, 0.00000035) | < 0.001 |
Diffuse Plaques/µm², median (CI) | 0.00000000 (0.00000000, 0.00000002) | 0 (0, 0) | 0.00000023 (0.00000012, 0.00000038) | 0.00000023 (0.00000019, 0.00000035) | < 0.001 |
CAA/µm², median (CI) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.88 |