Table 1 Demographics of included cases from the University of Kentucky Alzheimer’s Disease Research Center (UK-ADRC) autopsy cohort. LATE-NC stage number was determined based on the latest consensus-based pathologic criteria [5]. The Thal phases is a method for scoring amyloid plaque distribution. Braak staging is used to score tau pathology distribution. Postmortem interval (PMI) is the time elapsed since the patient’s death and the autopsy, given in hours
From: A pathologic study of Perivascular pTDP-43 Lin bodies in LATE-NC
Case | LATE-NC Stage | Thal Phase (Amyloid) | Braak Stage (Tau) | Clinical diagnosis | Age of death | Sex | PMI | APOE |
|---|---|---|---|---|---|---|---|---|
pTDP-43-positive cases | ||||||||
1 | 3 | 0 | 0 | Demented | 91 | F | 2.5 | ε2/ε3 |
2 | 3 | 4 | 3 | Normal | 93 | F | 2.6 | ε3/ε4 |
3 | 2 | 5 | 5 | Demented | 89 | F | 3.1 | ε3/ε3 |
4 | 2 | 5 | 5 | Demented | 77 | M | 9.1 | ε3/ε3 |
5 | 3 | 5 | 6 | Demented | 76 | M | 7.5 | Â |
pTDP-43-negative cases | ||||||||
6 | 0 | 5 | 5 | Demented | 88 | F | 3.8 | ε3/ε4 |
7 | 0 | 5 | 6 | Demented | 72 | M | 11.9 | ε3/ε4 |
8 | 0 | 5 | 5 | Demented | 87 | F | 15.5 | ε3/ε3 |
9 | 0 | 5 | 6 | Demented | 68 | M | 8.8 | ε3/ε4 |
10 | 0 | 5 | 6 | Demented | 64 | F | 5.4 | ε3/ε4 |