Table 1 Molecular characteristics of 19 CIC-fused tumors

Case 1

CIC::LEUTX

CIC_HGNET

LEUTX loss

Gain: 1q,2,3,6,8,12,14,17,19,20,21; Loss: 10

Case 2

CIC::LEUTX

near GG

LEUTX loss

Flat

Case 3

CIC::LEUTX

Undefined

LEUTX gain

Loss: 22q

Case 4

CIC::LEUTX

CIC_Sarcoma

LEUTX loss

Gain: 8,12,17,19; Loss: 13q

Case 5

CIC::LEUTX

CIC_Sarcoma

LEUTX loss

Flat

Case 6

CIC::LEUTX

CIC_Sarcoma

LEUTX gain

Gain: 1q, partial 2q, 19.

Case 7

CIC::NUTM1

CIC_Sarcoma

CIC gain

Gain: 5, 8, 16, 17, 21q

Case 8

CIC::NUTM1

CIC_Sarcoma

NUTM1 gain

Loss: 19p

Case 9

CIC: NUTM1

N/A

N/A

N/A

Case 10

CIC::NUTM1

CIC_Sarcoma

NUTM1 loss

Gain: 6; Loss: 7

Case 11

CIC::DUX4

CIC_Sarcoma

N/A*

Gain: 19, 22q

Case 12

CIC::FOXO4

CIC_Sarcoma

CIC gain

Flat

Case 13

CIC::NUTM1

CIC_Sarcoma

None

Flat

Case 14

CIC::NUTM1

N/A

N/A

N/A

Case 15

CIC-DUX4

CIC_Sarcoma

None

Gain: 8,19; Loss: 22q

Case 16

CIC-DUX4

N/A

N/A

N/A

Case 17

CIC-FBXO4

N/A

N/A

N/A

Case 18

CIC-DUX4

CIC_Sarcoma

CIC gain

Gain: partial 1q,6,18,22;

Loss: partial 1p, partial 1q,7,13q

Case 19

CIC-intergenic rearrangement

N/A

N/A

N/A