Fig. 1
From: Pediatric central nervous system tumor with CIC::LEUTX fusion: a diagnostic challenge
Methylation based t-distributed stochastic neighbor embedding (t-SNE) analysis of 12 CIC-fused CNS tumours (colored in gray) and 2 peripheral tumors harboring CIC::DUX4 fusion (colored in red). All cases were clustered to conventional CIC-altered sarcoma except for case 1, case 2 and case 3 with CIC::LEUTX fusion. AB_MN1 MC Astroblastoma MN1-altered, BCOR_ITD MC CNS tumour with BCOR internal tandem duplication, CIC_Sarcoma MC CIC-altered sarcoma, CNSNB_FOXR2 MC CNS neuroblastoma FOXR2-activated, CIC_HGNET MC high-grade neuroepithelial tumor CIC fusion-positive, EWS MC Ewing sarcoma, EPN_SPINE MC spinal ependymoma, EPN_ZFTA MC ependymoma ZFTA fusion-positive, ETMR MC Embryonal tumour with multilayered rosettes, GG MC Ganglioglioma, GBM_RTKII MC glioblastoma RTKII subtype, LGG_MYB MC diffuse astrocytoma MYB altered, PXA MC pleomorphic xanthoastrocytoma, SFT MC solitary fibrous tumor