Fig. 2
From: Altered brain expression and cerebrospinal fluid levels of TIMP4 in cerebral amyloid angiopathy
TIMP4 levels in CSF and serum. a CSF TIMP4 levels were decreased in patients with CAA compared to controls. b Serum TIMP4 levels were increased in patients with CAA compared to controls (y-axis has a log2 scale for visualization purposes). c The CSF:serum ratio of TIMP4 (Q-TIMP4) was lower in patients with CAA than controls. d CSF TIMP4 levels were associated with CSF levels of Aβ40 in the combined group of patients with CAA and controls. e CSF TIMP4 levels were not associated with CSF levels of Aβ42 in the combined group of patients with CAA and controls. d–e: Open circles: patients with CAA; closed circles: controls. f CSF TIMP4 levels were decreased in patients that had experienced a symptomatic ICH. g–i The MMP2:TIMP4, MMP9:TIMP4, and MMP14:TIMP4 ratios were increased in patients with CAA compared to controls. CAA, cerebral amyloid angiopathy; ICH, intracerebral haemorhage; CSF, cerebrospinal fluid. *p ≤ 0.05; **p ≤ 0.01