Fig. 1
From: Altered brain expression and cerebrospinal fluid levels of TIMP4 in cerebral amyloid angiopathy
Immunohistochemical analysis of TIMP4 in human brain tissue. a–c Representative examples of vascular TIMP4 staining in control (a), CAA-NH (b), and CAA-ICH (c) tissue. Upper panels show microscopic images at 10× magnification (scalebar = 100 µm), lower panels show depicted area at 63× magnification (scalebar = 20 µm). d Both CAA-NH and CAA-ICH cases had significantly higher TIMP4 scores compared to controls, and in addition, CAA-ICH cases had higher TIMP4 scores than CAA-NH cases. e TIMP4 score correlated to CAA grade in the CAA-NH and CAA-ICH groups (e). *p ≤ 0.05; ***p ≤ 0.001