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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy

Fig. 2

Neuropathological findings. Macroscopic examination showed selective hippocampal atrophy (a). Klüver–Barrera staining revealed severe neuronal loss in the hippocampal CA1 region (b). Gallyas staining showed abundant neurofibrillary tangles (NFTs), predominantly extracellular ghost tangles (c, d). Methenamine silver staining showed few plaques but abundant extracellular ghost tangles (e, f [magnified image of square in panel e]). Phosphorylated tau immunostaining showed NFTs distributed in the temporal lobe (g). Amyloid β immunostaining shows a mixture of diffuse and cored plaques in amounts up to moderate (h; taken in the middle temporal gyrus). Immunoblot analysis of sarkosyl-insoluble tau. Western blotting with an anti-tau antibody (clone T46, mouse monoclonal, dilution 1:1000, Thermo Fisher Scientific, Rockford, USA) detected full-length hyperphosphorylated tau bands with apparent molecular weight of 60, 64, and 68 kDa, consistent with NFT-predominant dementia/primary age-related tauopathy or Alzheimer’s disease tau banding pattern (i). Scale bars: 1 cm (a), 1 mm (b, c, and e), 50 μm (d), 20 μm (f), 5 mm (g), and 100 μm (h)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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