Fig. 5

Methylation profile of DMSs between CPT subtypes. a Volcano plot showing sites that are significantly hyper- and hypomethylated sites between CPP and CPC. b Heatmap of DMSs between CPP and CPC. Hierarchical clustering is performed by CpG site (column) and sample (row) according to the methylation pattern. The top of the figure indicates the genomic regions in which each site is located. c Boxplot of the degree of methylation in four types of repeat regions, grouped by CPT subtype. Significant differences between groups are indicated by asterisks.: *P < 0.05, **P < 0.01 as calculated by t test. d Copy number ratio, expression, and methylation of AK1 in different CPT subtypes. Significant differences between groups are indicated by asterisks.: *P < 0.05, **P < 0.01, ***P < 0.001 as calculated by the Wilcoxon rank-sum test