Increase in wasteosomes (corpora amylacea) in frontotemporal lobar degeneration with specific detection of tau, TDP-43 and FUS pathology

Table 2 Regional analysis of the wasteosome accumulation

	Control	FTLD-tau	FTLD-TDP	FTLD-FUS	p value adjusted
Hippocampal sulcus	1.4 ± 1.4	2.6 ± 1.4	2.5 ± 1.4	3.0 ± 0.5	0.0048^a
					0.012^b
Fimbria	2.5 ± 1.5	3.0 ± 1.3	2.9 ± 1.4	4.7 ± 0.5	0.010^c
					0.031^d
Periventricular area (hippocampus)	0.7 ± 1.1	0.9 ± 1.2	1.0 ± 1.1	2.9 ± 1.5	0.018^c,d,e

The regional analysis revealed significant differences among FTLD subtypes in the hippocampal sulcus, the fimbria and the periventricular areas of the hippocampus. Data shown as mean ± SD. Differences between groups were calculated using permutation tests with age at death and sex added as covariables. p values adjusted for multiple comparisons are only shown for the significant cases. ^aControls vs FTLD-tau; ^bcontrols vs FTLD-TDP; ^cFTLD-tau vs FTLD-FUS; ^dcontrols vs FTLD-FUS; ^eFTLD-TDP vs FTLD-FUS

ISSN: 2051-5960