Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial

Table 4 Pearson’s r correlations between peri-venular or peri-arteriolar AP with cognitive status and brain imaging parameters

Vascular type		MOCA n = 24–28		CDR n = 24–28		HV n = 19–22		Number of WMHI n = 17–20
Vascular type		r	P	r	P	r	P	r	P
Perivascular AP	Total	0.03	ns	0.46	0.01	− 0.47	0.028	0.34	ns
	Primary Br (total)	0.29	ns	− 0.15	ns	0.09	ns	− 0.24	ns
	Primary Br—main	0.19	ns	0.04	ns	− 0.20	ns	0.01	ns
	Primary Br—small	0.30	ns	− 0.21	ns	0.19	ns	− 0.31	0.045
	Secondary Br (total)	− 0.38	0.05	0.56	0.0021	− 0.41	ns	0.56	0.010
	Secondary Br—main	− 0.11	ns	0.40	0.034	− 0.27	ns	0.48	0.033
	Secondary Br—small	− 0.42	0.02	0.49	0.0078	− 0.40	ns	0.45	0.047
	Tertiary Br	− 0.07	ns	0.53	0.0040	− 0.55	0.0087	0.44	0.052
Peri- Venular AP	Total	− 0.26	ns	0.66	0.0001	− 0.51	0.016	0.40	ns
	Primary Br (total)	0.27	ns	− 0.06	ns	0.02	ns	− 0.33	ns
	Primary Br—main	0.20	ns	0.05	ns	− 0.15	ns	− 0.07	ns
	Primary Br—small	0.27	ns	− 0.12	ns	0.14	ns	− 0.45	0.045
	Secondary Br (total)	− 0.44	0.022	0.31	ns	− 0.24	ns	0.43	ns
	Secondary Br—main	− 0.03	ns	0.21	ns	− 0.34	ns	0.56	0.013
	Secondary Br—small	− 0.51	0.0063	0.25	ns	− 0.11	ns	0.15	ns
	Tertiary Br	− 0.38	ns	0.61	0.0016	− 0.51	0.026	0.52	0.032
Peri- Arteriolar AP	Total	0.21	ns	0.24	ns	− 0.37	ns	0.23	ns
	Primary Br (total)	0.25	ns	− 0.19	ns	0.12	ns	− 0.14	ns
	Primary Br—main	0.10	ns	0.02	ns	− 0.21	ns	0.11	ns
	Primary Br—small	0.25	ns	− 0.16	ns	0.06	ns	− 0.13	ns
	Secondary Br (total)	− 0.24	ns	0.51	0.0055	− 0.42	ns	0.53	0.016
	Secondary Br—main	− 0.13	ns	0.42	0.026	− 0.19	ns	0.31	ns
	Secondary Br—small	− 0.23	ns	0.43	0.022	− 0.42	0.049	0.49	0.028
	Tertiary Br	0.18	ns	0.19	ns	− 0.46	0.033	0.13	ns

Bolded values are significant after Holms-Bonferroni multiple comparisons correction
AP amyloid plaque, Br branch, CDR clinical dementia rating, HV hippocampal volume, MOCA Montreal Cognitive Assessment, WMHI White matter hyperintensities

ISSN: 2051-5960