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Table 3 Retinal perivascular amyloid plaques (AP) separated by MOCA score

From: Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial

Vascular type

MOCA > 26

MOCA ≤ 26

Fold change

Statistics

Mean

SD

n

Mean

SD

n

FC [95% CI]

P value

Perivascular

AP

Total

86.40

29.27

15

88.85

29.27

13

1.0 [0.76, 1.30]

0.83

Primary Br (total)

38.60

28.06

15

21.15

18.48

13

0.6 [0.20, 0.89]

0.053#

Primary Br—main

11.13

6.75

15

6.38

6.87

13

0.6 [0.18, 0.97]

0.077

Primary Br—small

27.47

23.15

15

14.77

13.02

13

0.5 [0.18, 0.90]

0.091#

Secondary Br (total)

22.43

11.24

14

37.62

12.09

13

1.7 [1.12, 2.23]

0.002

Secondary Br—main

11.93

5.96

15

14.23

6.87

13

1.2 [0.74, 1.65]

0.35

Secondary Br—small

12.67

10.71

15

23.38

8.51

13

1.8 [0.93, 2.76]

0.0075

Tertiary Br

21.93

13.02

15

29.00

21.80

13

1.3 [0.62, 2.03]

0.34#

Peri-

Venular AP

Total

32.20

10.60

15

39.46

14.09

13

1.2 [0.90, 1.55]

0.13

Primary Br (total)

17.93

10.73

15

9.31

9.40

13

0.5 [0.18, 0.86]

0.034

Primary Br—main

7.13

4.09

15

4.00

5.79

13

0.7 [0.07, 1.05]

0.11

Primary Br—small

10.80

8.17

15

5.31

4.68

13

0.5 [0.18, 0.81]

0.042

Secondary Br (total)

7.64

4.34

14

15.69

3.77

13

2.0 [1.35, 2.75]

 < 0.0001

Secondary Br—main

4.14

2.80

14

5.23

2.95

13

1.7 [0.64, 1.88]

0.33

Secondary Br—small

3.50

3.13

14

10.46

3.26

13

3.0 [1.42, 4.55]

 < 0.0001

Tertiary Br

7.67

6.50

12

15.50

14.30

12

2.0 [0.51, 3.54]

0.10#

Peri-

Arteriolar AP

Total

54.20

21.62

15

49.38

17.60

13

0.9 [0.64, 1.18]

0.53

Primary Br (total)

20.67

20.70

15

11.85

11.99

13

0.8 [0.12, 1.02]

0.42#

Primary Br—main

4.00

3.89

15

2.38

2.29

13

0.6 [0.15, 1.05]

0.20

Primary Br—small

17.86

17.78

14

10.25

10.85

12

0.6 [0.09, 1.05]

0.33#

Secondary Br (total)

17.47

11.94

15

21.92

11.29

13

1.3 [0.67, 1.84]

0.32

Secondary Br—main

8.07

4.13

15

9.00

4.85

13

1.1 [0.66, 1.57]

0.59

Secondary Br—small

9.40

10.25

15

12.92

8.50

13

1.4 [0.43, 2.32]

0.11#

Tertiary Br

15.80

10.97

15

15.92

10.26

12

1.0 [0.47, 1.54]

0.98

  1. Statistical analysis was established using two-tailed unpaired Student’s t test or # Mann–Whitney. *P < 0.05, **P < 0.01, ****P < 0.0001
  2. AP amyloid plaque, Br branch, FC fold change, MOCA Montreal Cognitive Assessment, SD standard deviation