Fig. 3
From: Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
Cryo-EM structures of tau PHF and SF conformations from DS case 1. A Representative electron micrograph of amyloid filaments from the frontal cortex of DS case 1 showing PHF and SF segments (left image; light and dark blue asterisks, respectively) and corresponding 2D class averages (middle images) and cross-section projection views of the conformations (right images). B Final cryo-EM density maps of the PHF and SF at 2.7-Å and 2.9-Å resolution, respectively. Asterisks indicate extra densities previously observed in structures from AD, and boxes show each protofilament interface, enlarged in (C). C Single protofilament cryo-EM map (mesh) with the fitted atomic model for the PHF (left) and SF (right), including tau residues G304 for PHF (G303 for SF) to E380 and an enlarged view of the protofilament interface