Fig. 1
From: Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
Fluorescence images of immunolabeled Aβ plaques and tau tangles in DS brain samples used for cryo–electron microscopy experiments. Formalin-fixed frontal cortex sections stained with antibodies against total Aβ (magenta) and the phosphorylated tau S262 epitope (white) in DS case 4, 36 years old (A–C), DS case 3, 46 years old (D–F), and DS case 2, 51 years old (G–I). Individual fluorescence channels were converted to grayscale and inverted for phosphorylated tau (B, E, H) and Aβ (C, F, I). Scale bar = 2 mm. Inset dimensions = 0.6 mm2