Fig. 7

αSynΔC inclusion pathology within CD11b reactive cells in the CNS of TgM20^+/- mice seeded with MSA lysates and PFFs. Representative co-immunofluorescence images from TgM20^+/- mice brain sections seeded with (a) MSA or (b) PFFs. Sections were double-labeled with CD11b, a marker of activated microglia, and αSynΔC-specific antibodies 2G5 (αSynΔC103), 1A2 (αSynΔC114), 10A4 (αSynΔC122), 5C1 (αSynΔC125) and 2G7 (αSynΔC129). Scale bars: 50 µm; 25 µm (insets). c Images were assessed based on the frequency of αSynΔC variants co-localizing with CD11b+ cells, categorized as frequent, sparse, rare, or absent (none). This figure highlights αSynΔC variants that were observed either frequently or sparsely within CD11b+ cells. Representative images depicted are of the piriform cortex (2G5 in a and 1A2 in b), the entorhinal cortex (2G7 in a), and the subiculum (2G5 in b)