Fig. 6

αSynΔC Inclusion Pathology within CD11b Reactive Cells in the CNS of TgM83^+/- Mice Seeded with MSA Lysates and PFFs. Representative co-immunofluorescence images from TgM83^+/- mice brain sections seeded with (a) MSA or (b) PFFs. Sections were double-labeled with CD11b, a marker of activated microglia, and αSynΔC-specific antibodies 2G5, (αSynΔC103), 1A2 (αSynΔC114), 10A4 (αSynΔC122), 5C1 (αSynΔC125) and 2G7 (αSynΔC129). Scale bars: 50 µm; 25 µm (insets). c Images were assessed based on the frequency of αSynΔC variants co-localizing with CD11b+ cells, categorized as frequent, sparse, rare, or absent (none). This figure highlights αSynΔC variants that were observed either frequently or sparsely within CD11b+ cells. Representative images depicted are of the midbrain (2G5 in a) and the medulla (1A2 in a and b and 2G5 in b)