Fig. 4

Summary of visual performance in controls and 5xFAD substrains. Impaired A) contrast sensitivity but not B) acuity was noted in 5xFAD B6J mice (WT, n = 5; 5xFAD, n = 5); 5xFAD B6NTac mice visual indices were unremarkable (C, D; 4 mo, middle row [WT, n = 5; 5xFAD, n = 11]; 10 mo, bottom row [E, F; WT, n = 7; 5xFAD, n = 7]). Black horizontal line indicates P < 0.05 (two-tailed, linear mixed-model analysis; mean ± 95% CI); n = 5 WT, n = 5 5xFAD. Individual data points represent the measured value for each mouse. Potential strain differences in both indices did not depend on which direction the grating moved, and means did not differ between directions so averages over both directions are presented